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. 2016 May 10;6:25593. doi: 10.1038/srep25593

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(a,b) Absence of gold particles attached to B314(V) control spirochetes probed with secondary syphilis (SS) patient serum followed by anti-human gold conjugated antibodies (at 25x and 100x magnifications) confirms that this serum does not recognize surface proteins of B. burgdorferi strain B314. (c) Immuno-SEM imaging of B314(pTP) probed with SS serum at high magnification (100x) showed attached gold particles only on some of the B. burgdorferi cells (arrows). Arrowheads indicate the spirochetes without any gold particles attached. (d,e) Absence of attached gold particles by Back Scattered Imaging (BSI) of B314(V) in the field shown in the Fig. 3a,b, respectively confirms that the patient serum does not recognize surface proteins of B314 strain. (f) Stochastic expression of TP0435 on B314(pTP) surface in Fig. 3c is more clearly visible in BSI of the same field.