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. 2016 May 10;6:25593. doi: 10.1038/srep25593

Figure 6. TP0435 is an adhesin that facilitates binding to epithelial, Glial and placental cells.

Figure 6

(a) B314(pTP) strain is adherent to BeWo and HEK 293 cells with 50- and 70-fold increase in binding as compared to the control B314(V) strain to these cells as detected by measurement of light emitted by the attached luminescent spirochetes. NC indicates ‘No Cell’ control. (b) Adherence levels depicted in ‘a’ are quantified. Attachment of B314(pTP) is significantly higher than B314(V) binding to the respective cell lines as determined by student T test (**p < 0.001). Binding of B314(V) to both cell lines is not significantly different from B314(pTP) strain binding to NC control. (c) Binding of 35S-labeled B314(pTP) strain to HEK 293 and rat C6 Glioma cells increased in statistically significant manner as compared to B314(V) binding (*P < 0.001 by student T test). Binding of B314(V) to both cells was also significantly higher (*P < 0.001) as compared to binding of this strain to NC control.