Table 4.
Reported mutations associated with changes in drug sensitivity to inhibit IKr.
| Gene/subunit | Mutation | Drug | Ion Current | Effect | Ref |
|---|---|---|---|---|---|
| KCNE2 /MiRP1 | Q9E-MiRP1 | Clarithromycin | IKr | Increased sensitivity to inhibition | [35] |
| KCNE1 / Mink | D76N and D85N- Mink | Clarithromycin | IKr | Increased sensitivity to inhibition | [36] |
| KCNE2 /MiRP1 | T8A-MiRP1 | Sulfamethoxazole | IKr | Increased sensitivity to inhibition | [109] |
| KCNE2/SCNA/KCNE1 | No mutation or polymorphisms on KCNE2-SCNA or KCNE1 were found | Risperidone | IKr | Increased sensitivity to inhibition | [124] |