Table 3. Different features employed to study their contribution towards observed correlation between RBPs and their post-transcriptional targets, in the transcript centric modelling.
Variable | Feature name | Description |
---|---|---|
Response | Correlation coefficient of RBP with target transcript | For each RBP, the correlation coefficient of the selected protein coding transcript (or protein expression at protein level) with each target transcript was selected as the response variable. |
Predictor | CLIP Signal | CLIP peaks in the bed format obtained from CLIPdb28 come with a P- value signifying the intensity of the CLIP binding for each binding site. The median P - value of the binding sites which were mapped on to the target, for each RBP, was calculated. |
Distance of binding site from 5′ end | The distance of the start of the binding site from the 5′ end of each target transcript was calculated. | |
Distance of binding site from 3′ end | The distance of the start of the binding site from the 3′ end of each target transcript was calculated. | |
Transcript Length | The length of each target transcript was obtained from Ensembl51. | |
Transcript Type | The biotype of each target transcript was also obtained from Ensembl51. |
For each feature details about how it was computed is also listed.