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. 2016 May 10;6:25660. doi: 10.1038/srep25660

Figure 4. Spontaneous hippocampal-onset seizures observed in sham perforant pathway transection (Sham PPT) and PPT rats after 8 h of perforant pathway stimulation.

Figure 4

Traces (A) (Sham PPT) and (B) (PPT) represent 65 seconds of activity recorded from the hippocampal granule cell layer in freely moving rats. Asterisks denote the first overt seizure behavior (forepaw clonus leading to rearing). (C) Mean latency to the first spontaneous seizure. The first seizures manifested after an average of 16.8 + 1.9 d (n = 6) in Sham PPT animals and 15.2 + 1.5 d in the PPT group (n = 5). (D) Mean spontaneous seizure duration. A total of twenty-six seizures were recorded from Sham PPT and PPT animals. Mean seizure length was 77 seconds for Sham PPT and 87 seconds for PPT rats. PPT had no affect on either the length of time between PPS and the first seizure (latent period) or seizure duration (p > 0.05). Calibration bars: 3 s, 4 mV.