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. 2016 May 10;6:25660. doi: 10.1038/srep25660

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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2 months after 8 h perforant pathway stimulation in control (A), sham perforant pathway transection (Sham PPT, (B), and PPT (C) groups. NeuN-immunostained transverse sections demonstrating similar neuron loss in both experimental groups. Note the severe loss of CA3 and CA1 neurons in the hippocampus. Arrows in panel C denote the location of the mechanical lesion. (D) Quantification of hippocampal neuron loss. Neuron counts were performed on matching NeuN-immunostained sections. CA3 and CA1 were combined as the border between these regions was unclear in experimental animals. Although substantial neuron loss was seen in the hilus (h) and CA regions in both Sham PPT and PPT groups when compared with control (n = 5 per group, p < 0.001), there was no significant difference between groups (p > 0.05), demonstrating no effect of PPT on neurodegeneration.