Table 1. Methodological quality of the 46 studies according to the QUADAS questionnaire.
| Study | Year | Country/region | Patients |
Test |
Result |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Author | Patients are representative of the question | Selection criteria described | Biopsy is performed in all patients | PCA3 assay described | Selection of controls | Number for cores per biopsy ≥10 | Blinded gold standard interpretation | Cut-off reported | ||
| Hessels | 2003 | Netherlands/Eur | Yes | Yes | No | Yes | Yes | No | No | Yes |
| Fradet | 2004 | Canada | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes |
| Tinzel | 2004 | Austria/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Groskopf | 2006 | US | Yes | Yes | Yes | Yes | No | Unclear | No | Yes |
| van Gils | 2007 | Netherlands/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| van Gils | 2007 | Netherlands/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Marks | 2007 | US, Canada | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Deras | 2008 | US, Canada | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Haese | 2008 | Europe | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes |
| Laxman | 2008 | US | Yes | Yes | Yes | Yes | No | Unclear | Yes | Yes |
| Ouyang | 2009 | US | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Shappell | 2009 | US | Yes | Yes | No | Yes | No | Unclear | No | Yes |
| Wang | 2009 | US | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Mearini | 2009 | Italy/Eur | Yes | Yes | Yes | Yes | No | Yes | No | Yes |
| Henderson | 2010 | UK/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Aubin | 2010 | US | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Auprich | 2010 | Europe | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Morotel | 2010 | Spain/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Nyberg | 2010 | Sweden/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Roobol | 2010 | Netherlands/Eur | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes |
| Rigau | 2010 | Spain/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Shen | 2010 | China/Asian | Yes | Yes | Yes | Yes | No | Unclear | Yes | Yes |
| Schilling | 2010 | Germany/Eur | Yes | Yes | Yes | Yes | Unclear | Yes | No | Yes |
| Rubio-Briones | 2011 | Spain/Eur | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes |
| Adam | 2011 | South Africa | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Cao | 2011 | China/Asian | Yes | Yes | Unclear | Yes | No | Yes | No | Yes |
| Ochiai | 2011 | Japan | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes |
| Perdona | 2011 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Taille | 2011 | Europe | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Babera | 2012 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | No |
| CF Ng | 2012 | China/Asian | Yes | Yes | Yes | Yes | Yes | Yes | Yes | No |
| Crawford | 2012 | US | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Pepe | 2012 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Pepe | 2012 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Sciarra | 2012 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Wu | 2012 | US | Yes | Yes | Yes | Yes | No | Yes | No | Yes |
| Ferro | 2013 | Europe | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Goode | 2013 | US | Yes | Yes | Yes | Yes | No | Yes | No | Yes |
| Ochiai | 2013 | Japan | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes |
| Stephan | 2013 | Germany/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Perdona‘ | 2013 | Italy/EurCaucasian | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Salagierski | 2013 | Poland/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Scattoni | 2013 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| Chevli | 2013 | USA | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes |
| Giuseppe | 2014 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes |
| Francesco | 2014 | Italy/Eur | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |