Figure 11. Checking the validity of sampled points.

The Euclidean distance of the backbone atom Cα is calculated between the sampled point of the i^th residue and each of other residues. The sampled point is accepted if it satisfies the spatial restraints without broken chains (i.e. too far away from adjacent atoms: d_ij > 4.5 Å) and atom clashes (too close to other atoms: d_ik < 3.5 Å).