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. 2016 May 10;6:25680. doi: 10.1038/srep25680

Figure 1. Current models for biotin uptake and BirA biotin protein ligase/repressor functions.

Figure 1

(A) Proposed biotin uptake and utilization pathway in L. lactis. The two half-reactions of BirA-mediated BCCP biotinylation are shown. (B) E. coli BirA represses the biotin synthesis pathway (C). B. melitensis BioR represses expression of the biotin synthesis pathway and the biotin transport system (D). Transcriptional repression of the bioY gene by the BirA of S. suis 2 (E). BirA1 represses expression of the bioY gene in L. lactis.