TABLE 2.
Representative serotypes, common MLST types, and common resistance determinant patterns found within penicillin-resistant strains recovered through the ABCs program from individuals of all ages during 1998 to 2015
| Clonal complex reference strain (serotype, MLST type) | Associated serotype(s) | Common MLST type(s) | Predominant resistance-associated PBP transpeptidase profile(s)a | Common non-beta-lactam resistance determinant profile(s) |
|---|---|---|---|---|
| PMEN-1 (23F, ST81) | 23F, 19F, 19Aa | ST81, ST2346b | 15/12/18 | mef, cat, tetM, folA-I100L, folP insertion; ermB, cat, tetM, folA-I100L, folP insertion |
| PMEN-2 (6B, ST90) | 6B | ST90 | 34/57/56 | ermB, cat, tetM, folA-I100L, folP insertion; ermB, tetM, folA-I100L, folP insertion |
| PMEN-3 (9V, ST156) | 9V, 14, 19A,b 35B,b 11A,c 31c | ST156,ST166 | 15/12/18 | mef, folA-I100L, folP insertion; ermB, tetM, folA-I100L, folP insertion; folA-I100L, folP insertion |
| PMEN-4 (23F, ST37) | 23F | ST37 | 27/38/52 | mef, folA-I100L, folP insertion |
| PMEN-5 (14, ST18) | 14 | ST18 | Not available | ermB, cat, tetM, folA-I100L, folP insertion |
| PMEN-9 (14, ST9) | 14 | ST13 | 27/36/8 | mef, folA-I100L, folP insertion |
| PMEN-14 (19F, ST236) | 19F, 19A,b 3c | ST236, ST271, ST320,b ST1451b | 13/54/33, 13/11/16,b 13/11/33,b 13/14/26b | ermB, mef, tetM, folA-I100L, folP insertion |
| PMEN-15 (23F, ST242) | 23F, 6Ac | ST242 | 13/31/73, 13/31/146c | mef, tetM, folA-I100L, folP insertion; ermB, tetM, folP insertionb |
| PMEN-17 (6B, ST384) | 6B, 6A | ST384, ST147 | 41/36/8 | mef, tetM, folA-I100L, folP insertion |
| PMEN-18 (14, ST67) | 14 | 38/16/8, 38/16/36 | ermB, tetM, folA-I100L, folP insertion | |
| PMEN-23 (6A, ST376) | 6A, 19Ab | ST376, ST1339b | 42/42/8, 27/30/8b | mef, folA-I100L, folP insertion |
| PMEN-24 (35B, ST377) | 35B, 19Ab | ST558 | 4/7/7 | mef |
| PMEN-32 (14, ST230) | 19Aa | ST230, ST276 | 17/15/18, 17/7/8 | tetM, folA-I100L, folP insertion |
a
PBP profile data and matching transpeptidase sequence databases are available in reference 50.
b
First observed during the post-PCV7 period from 2002 to 2009.
c
First observed during the post-PCV13 period from 2012 to 2015.