Table 3.
Baseline Biochemical Parameters (Mean ± SD), and Prognostic Markers in Cases With and Without Prior History of Acute Decompensation and With Single and Multiple Acute Predispositions.
| Biochemical parameters and prognostic markers | Cases without prior H/O AD (N = 67) | Cases with prior H/O AD (N = 56) | ‘P’ value | Cases with single acute insult (N = 88) | Cases with multiple acute insult (N = 35) | ‘P’ value |
|---|---|---|---|---|---|---|
| TLC/cmma | 9050 (4400–32,000) | 9000 (3800–20,000) | 0.63 | 8600 (3800–20,000) | 10,400 (5200–32,000) | 0.02 |
| Urea (mg/dl)a | 27 (5.1–152) | 29.5 (14–223) | 0.95 | 26 (14–223) | 32 (5.1–152) | 0.18 |
| Creatinine (mg/dl)a | 1.2 (0.6–6.8) | 1 (0.5–8.1) | 0.01 | 1.08 (0.5–8.1) | 1.1 (0.5–5.4) | 0.38 |
| Sodium (mmol/L) | 132.10 ± 6.69 | 131.36 ±6.45 | 0.53 | 131.89 ±5.76 | 131.46 ± 8.35 | 0.74 |
| Total bilirubin (mg/dl)a | 9.2 (5.1–36) | 7.8 (5.2–40) | 0.19 | 9.1 (5.1–40) | 7.8 (5.1–36) | 0.67 |
| AST (IU/L)a | 110 (27–599) | 86 (23–509) | 0.054 | 98 (23–599) | 96 (27–492) | 0.51 |
| ALT (IU/L)a | 71 (20–330) | 55 (26–370) | 0.004 | 64 (20–370) | 63 (29–325) | 0.81 |
| ALP (IU/L)a | 263 (69–975) | 259 (61–920) | 0.59 | 266 (61–975) | 235 (97–653) | 0.16 |
| Albumin (g/dl) | 2.75 ± 0.54 | 2.71 ± 0.57 | 0.68 | 2.76 ± 0.53 | 2.65 ± 0.62 | 0.31 |
| INR (PT) | 2.38 ± 0.78 | 2.56 ± 0.83 | 0.24 | 2.42 ±0.84 | 2.56 ± 0.71 | 0.4 |
| CTP | 12.17 ± 1.21 | 12.37 ± 1.33 | 0.38 | 12.17 ±1.32 | 12.57 ± 1.01 | 0.1 |
| MELD | 28.21 ± 7.48 | 26.61 ± 5.15 | 0.17 | 27.25 ± 6.85 | 28.20 ± 5.54 | 0.46 |
| MELD-Na | 30.18 ± 6.45 | 29.23 ± 4.42 | 0.34 | 29.48 ± 5.89 | 30.63 ± 4.61 | 0.30 |
N: number; SD: standard deviation; H/O AD: history of acute decompensation; TLC: total leukocyte count; AST: aspartate transaminase; ALT: alanine transaminase; ALP: alkaline phosphatase; INR (PT): International Normalized Ratio (Prothrombin Time); CTP: Child Turcotte Pugh; MELD: Model for End-Stage Liver Disease; MELD-Na: Model for End-Stage Liver Disease Sodium.
a
Median (range) value.