Table 2.
Frequencies of Thrombophilic Genetic Factors (THRGFs), PAI-14G-4G, MTHFR677TT, V Leiden 506Q and Prothrombin 20210A in Patients With Liver Cirrhosis (LC) Hepatocellular Carcinoma (HCC), Myeloproliferative Neoplasm (MPN), With (AD) and Without Associated Disease (WAD), vs Healthy Controls (HC).
| LC (%) | HCC (%) | MPN (%) | AD (%) | WAD (%) | Total SVT (A) (%) | HC (B) (%) | OR (95% CI) (A) vs (B) |
χ2 test P value |
|
|---|---|---|---|---|---|---|---|---|---|
| Number of patients | 350 (100) | 47 (100) | 37 (100) | 38 (100) | 10 (100) | 482 (100) | 150 (100) | – | – |
| PAI-1 4G-4G | 111 (31) | 15 (31) | 18 (48) | 23 (60) | 7 (70) | 174 (36) | 26 (17.3) | 2.70 (1.7–4.4) | 18.6 0.000 |
| MTHFR 677TT | 88 (25) | 17 (36) | 8 (21) | 10 (26) | 6 (60) | 129 (26) | 20 (13.3) | 2.38 (1.4–4.1) | 11.5 0.001 |
| V Leiden 506Q | 29 (8) | 1 (2) | 6 (16) | 4 (10) | 3 (30) | 42 (8) | 7 (4.6) | 2.0 (0.8–4.9) | 2.6 0.12 |
| Prothrombin 20210A | 18 (5) | 4 (8) | 2 (5) | 1 (2) | 2 (20) | 27 (5) | 4 (2.6) | 2.2 (0.7–7.4) | 2.1 0.15 |
| >1 THRGF | 52 (14) | 4 (8) | 5 (13) | 3 (7) | 6 (60) | 70 (14) | 2 (1.3) | 12.6 (3.0–75.1) | 19.7 0.000 |
| At least 1 THRGF | 189 (54) | 29 (61) | 29 (78) | 35 (92) | 10 (100) | 292 (60) | 54 (36.0) | 2.7 (1.8–4.1) | 27.9 0.000 |