Table 1.

Associations between PODXL expression and EGFR expression, BRAF, KRAS mutations and MSI status in colorectal cancer

PODXL	Cohort 1					p value	Cohort 2					p value	Cohort 3					p value
	0	1	2	3	4		0	1	2	3	4		0	1	2	3	4
N (%)	268 (50.0)	186 (34.7)	10 (1.9)	71 (13.2)	1 (0.2)		137 (50.7)	67 (24.8)	31 (11.5)	25 (9.3)	0 (0.0)		197 (56.3)	65 (18.6)	29 (8.3)	22 (6.3)	3 (0.9)
EGFR
Low	225 (87.5)	141 (77.9)	7 (70.0)	34 (48.6)	0 (0.0)	<0.001	106 (80.3)	55 (84.6)	22 (73.3)	12 (50.0)	0 (0.0)	0.008	171 (89.5)	55 (85.9)	21 (72.4)	10 (47.6)	0 (0.0)	<0.001
High	32 (12.5)	40 (22.1)	3 (30.0)	36 (51.4)	1 (100.0)		26 (19.7)	10 (15.4)	8 (26.7)	12 (50.0)	0 (0.0)		20 (10.5)	9 (14.1)	8 (27.6)	11 (52.4)	3 (100.0)
Missing	11	5		1			5	2	1	1			6	1		1
BRAF status
Wt	227 (90.8)	153 (85.5)	4 (40.0)	45 (70.3)	0 (0.0)	<0.001	N/A	N/A	N/A	N/A	N/A		123 (89.8)	33 (78.6)	12 (60.0)	13 (81.3)	0 (0.0)	<0.001
Mutated	23 (9.2)	26 (14.5)	6 (60.0)	19 (29.7)	1 (100.0)		N/A	N/A	N/A	N/A	N/A		14 (10.2)	9 (21.4)	8 (40.0)	3 (18.7)	2 (100.0)
Missing	18	7		7									60	23	9	6	1
KRAS status
Wt	153 (61.0)	118 (65.9)	9 (90.0)	41 (64.1)	1 (100.0)	0.312	N/A	N/A	N/A	N/A	N/A		75 (58.1)	29 (70.7)	17 (85.0)	8 (57.1)	2 (100.0)	0.095
Mutated	98 (39.0)	61 (34.1)	1 (10.0)	23 (35.9)	0 (0.0)		N/A	N/A	N/A	N/A	N/A		54 (41.9)	12 (29.3)	3 (15.0)	6 (42.9)	0 (0.0)
Missing	17	7		7									68	24	9	8	1
MSI status
MSS	227 (88.7)	146 (84.9)	0 (0.0)	52 (80.0)	1 (100.0)	<0.001	N/A	N/A	N/A	N/A	N/A		170 (86.7)	51 (81.0)	20 (69.0)	22 (100.0)	2 (66.7)	0.021
MSI	29 (11.3)	26 (15.1)	9 (100.0)	13 (20.0)	0 (0.0)		N/A	N/A	N/A	N/A	N/A		26 (13.3)	12 (19.0)	9 (31.0)	0 (0.0)	1 (33.3)
Missing	12	14	1	6									1	2