Fig. 1.

A number of viability-inhibiting compounds do not induce cell death. Scatter plot showing the comparison of average DSS over the panel of 19 different breast cancer cell lines computed using two a independent viability measurement assays (CellTiter-Blue and CellTiter-Glo) and b viability measurement (CellTiter-Glo) and cell death measurement (CellTox Green) assays. The black dotted line represents the equal score in the screens and the green solid line represents the linear regression. Blue symbols mark compounds with strong viability readout responses but with low to no cytotoxicity. c The major classes of compounds highlighted in panel B that inhibit the viability readout of the cells but do not effectively induce cell death