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. 2016 May 10;15:34. doi: 10.1186/s12943-016-0517-3

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© Gautam et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — An mTOR inhibitor antagonizes the effect of diverse classes of drugs in CAL-51. Scatter plot of DSS scored for combinatory effect of different compounds along with everolimus (10 nM) (Y-axis) on CAL-51 cell line compared to the single agent effects (X-axis). Plot a represents the DSS computed using cell death assay and plot b represents cell viability assay. Data points with DSS difference more than 10 are highlighted with different colors representing different classes of drugs as listed in the color legend. c Compounds whose effect is inhibited when combined with everolimus, as highlighted in panels (a) and (b)