Table 2.
Baseline Cluster Descriptive. Values shown are number of subjects, and percentage of total subjects [n (%)] unless stated
| Variable | Phenotype A (n = 15) | Phenotype B (n = 17) | Phenotype C (n = 39) | Phenotype D (n = 54) | p-value |
|---|---|---|---|---|---|
| FEV1 < 80 % | 12 (80.0) | 9 (52.9) | 37 (94.9) | 20 (37.0) | <0.01 |
| Beclamethasone or equivalent dose >1600mcg | 7 (46.7) | 2 (11.8) | 6 (15.4) | 4 (7.4) | <0.01 |
| AOO <20 year | 3 (20.0) | 7 (41.2) | 31 (79.5) | 17 (31.5) | <0.01 |
| ACQ ≤ 1 | 2 (13.3) | 5 (29.4) | 14 (35.9) | 24 (44.4) | 0.15 |
| Female | 6 (40.0) | 10 (58.8) | 12 (30.8) | 31 (57.4) | 0.05 |
| Severe asthmatic | 14 (93.3) | 10 (58.8) | 31 (79.5) | 22 (40.7) | <0.01 |
| Atopic | 11 (73.3) | 13 (76.5) | 34 (87.2) | 42 (77.8) | 0.58 |
| Non-Smoker | 9 (60.0) | 13 (76.5) | 28 (71.8) | 27 (50.0) | 0.09 |
| Age [mean(SD)] | 46.7 (13.4) | 44.9 (8.8) | 52.4 (12.6) | 47.5 (11.9) | 0.10 |
| BMI [mean (SD)] | 26.2 (3.8) | 40.1 (4.4) | 27.0 (3.9) | 25.4 (3.7) | <0.01 |
| Sputum Neutrophils (%) [mean (SD)] | 34.3 (27.4) | 51.0 (24.8) | 43.6 (29.2) | 47.5 (29.3) | 0.34 |
| Sputum Eosinophils (%) [mean (SD)] | 3.9 (5.3) | 33.5 (16.7) | 5.1 (6.5) | 5.8 (6.0) | <0.01 |
| FENO ppb [mean (SD)] | 28.7 (26.5) | 25.5 (23.8) | 29.7 (30.6) | 24.0 (21.4) | 0.74 |
Abbreviations: FEV 1 Forced Expiratory Volume at 1 s, ICS inhaled corticosteroid, AOO age of onset of asthma, ACQ Asthma Control Questionnaire score, BMI body mass index, F E NO fractional of exhaled nitric oxide in parts per billion (ppb). Chi-square test was used for categorical variables, and one-way ANOVA was performed for continuous variables