Table 5.
Comparison of Mean Absolute Change in Sputum eosinophils (%) and FEV1 (%) between subjects who changed cluster as opposed to those who did not change cluster
| Flux Period | Patients with no change in cluster | Patients with change in cluster | p-value |
|---|---|---|---|
| Baseline to 3 months N | 85 | 40 | |
| Absolute change in FEV1(%) Mean (SD) | 6.2 (5.6) | 12.1 (15.1) | 0.02 |
| Absolute change in Eos (%) Mean (SD) | 5.9 (6.2) | 16.7 (15.1) | <0.01 |
| Baseline to 6 months N | 97 | 28 | |
| Absolute change in FEV1(%) Mean (SD) | 5.6 (6.0) | 16.1 (17.0) | <0.01 |
| Absolute change in Eos(%) Mean (SD) | 6.1 (7.3) | 22.1 (15.9) | <0.01 |
| Baseline to 9 months N | 98 | 27 | |
| Absolute change in FEV1(%) Mean (SD) | 6.6 (5.9) | 16.7 (16.0) | <0.01 |
| Absolute change in Eos Mean (SD) | 7.9 (8.3) | 19.9 (14.3) | <0.01 |
| Baseline to 12 months N | 95 | 30 | |
| Absolute change in FEV1(%) Mean (SD) | 8.3 (7.8) | 15.1 (15.1) | 0.03 |
| Absolute change in Eos Mean (SD) | 7.8 (8.7) | 16.3 (14.2) | <0.01 |