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. 2016 May 10;14:129. doi: 10.1186/s12967-016-0875-z

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© Hall et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Immunofluorescence and genetic analysis indicates a BRCA2 mutation in the PA-018 PAAC model. a Immunofluorescence staining for BRCA1 and BRCA2. Panel i shows BRCA1 (red) expressed throughout the nucleus and cytoplasm in normal, PDAC, and the PAAC PDTX tissue. In panel ii, normal and PDAC tissue show co-localization of nuclear DAPI stain and BRCA2 but the PAAC PDTX tissue, does not have this co-localization, indicating that BRCA2 expression is confined to the cytoplasm. b Gene mutational analysis of BRCA2 confirms the presence a 5 base pair deletion on exon 10