Table 2.
Kinetics of laboratorial alterations at the time of diagnosis and during treatment. The median values ± interquartile range of laboratorial parameters at every point of the study
| Parameters (units) | Reference intervalsg | Day 0 | Day 30 | Day 180 | Day 365 |
|---|---|---|---|---|---|
| UPC ratioa | < 0.5 | 0.3 ± 0.7 | 0.2 ± 0.2 | 0.2 ± 0.5 | 0.1 ± 0.3 |
| Total protein (g/dl)b | 5.4–7.1 | 8.00 ± 3.05 | 7.08 ± 1.60 | 6.63 ± 0.67 | 6.70 ± 0.65 |
| Albumin (g/dl)c | 2.6–3.3 | 2.66 ± 0.89 | 2.72 ± 0.65 | 3.33 ± 0.54 | 3.36 ± 0.53 |
| Gamma-globulins (g/dl)d | 0.3–0.8 | 1.63 ± 3.03 | 0.91 ± 1.11 | 0.63 ± 0.28 | 0.61 ± 0.33 |
| Hematocrit (%)e | 40–61 | 36 ± 13 | 39 ± 10 | 44 ± 7 | 46 ± 9 |
| Hemoglobin (g/dl)f | 13.0–19.8 | 12.6 ± 4.2 | 13.7 ± 3.1 | 15.8 ± 2.6 | 16.3 + 4.0 |
aComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test, Z = -2.987 P = 0.003), day 180 (Z = -2.521 P = 0.012), day 365 (Z = -2.500 P = 0.012)]. Comparison between day 30 - day 180 (Z = -0.456, P = 0.649), day 30 - day 365 (Z = -0.533, P = 0.594) and day 180 - day 365 (Z = -1.122, P = 0.262)
bComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -3.676, P = 0.000237), day 180 (Z = -3.784, P = 0.000155) and day 365 (Z = -3.579, P = 0.000345)]. Comparison between day 30 - day 180 (Z = -2.707, P = 0.007), day 30 - day 365 (Z = -2.033, P = 0.042) and day 180 - day 365 (Z = -0.205, P = 0.83)
cComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.040, P = 0.041), day 180 (Z = -5.004, P < 0.0001) and day 365 (Z = -4.703, P < 0.0001)]. Comparison between day 30 - day 180 (Z = -4.342, P < 0.0001), day 30 - day 365 (Z = -3.530, P < 0.0001) and day 180 - day 365 (Z = -0.573, P = 0.566)
dComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -4116, P < 0.0001), day 180 (Z = -4.357, P < 0.0001) and day 365 (Z = -2.084, P = 0.037)]. Comparison between day 30 - day 180 (Z = -3.752, P = 0.000175), day 30 - day 365 (Z = -4.065, P < 0.0001) and day 180 - day 365 (Z = -0.379, P = 0.705)
eComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.655, P = 0.008), day 180 (Z = -4.379, P < 0.0001) and day 365 (Z = -3.977, P < 0.0001)]. Comparison between day 30 - day 180 (Z = -2.657, P = 0.008), day 30 - day 365 (Z = -3.322, P = 0.020) and day 180 - day 365 (Z = -1.202, P = 0.229)
fComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.806, P = 0.005), day 180 (Z = -4.243, P < 0.0001) and day 365 (Z = -3.521, P = 0.000431)]. Comparison between day 30 - day 180 (Z = -3.181, P = 0.001), day 30 - day 365 (Z = -3.124, P = 0.002) and day 180 - day 365 (Z = -1.384, P = 0.166)
gUAB hematological and biochemical laboratory reference intervals