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. 2016 May 9;35:44. doi: 10.1186/s40880-016-0107-1

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© Cacchione et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Histopatologic features of the spinal GBM of the conus medullaris. Microscopy demonstrates a neoplastic proliferation of polymorphous glial cells characterized by anisocaryosis and atypical mitosis. a Focal necrosis, calcifications, and areas with multinucleated cells are present (×40). b Immunohistochemistry shows positivity for glial fibrillary acidic protein (GFAP) and S100 and negativity for sinaptofisine, neurofilaments, and the epithelial membrane antigen (EMA) (×63). c The proliferation index (anti-Ki67) is 15% (×63)