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. Author manuscript; available in PMC: 2016 Sep 25.
Published in final edited form as: Circ Res. 2015 Sep 25;117(8):656–658. doi: 10.1161/CIRCRESAHA.115.307245

Figure 2. The role of IRF2BP2 in macrophage inflammation and atherosclerosis.

Figure 2

Macrophage deficiency in IRF2BP2 leads to increased lipid accumulation through increased lipid uptake and reduced efflux, accompanied by increased LPS-induced M1 activation and reduced IL-4 induced M2 activation. IRF2BP2 is required for the expression of the anti-inflammatory transcription factor KLF2. Restoring KLF2 in IRF2BP2 deficient macrophages attenuates inflammatory M1 activation and rescues anti-inflammatory M2 activation, and improves cholesterol handling. Ablation of IRF2BP2 in macrophages worsens atherosclerosis in mice and a deletion variant that lowers expression of IRF2BP2 and its target gene KLF2 predisposes to CHD in humans.