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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Transl Res. 2015 Apr 13;166(4):366–374. doi: 10.1016/j.trsl.2015.04.001

Figure 2.

Figure 2

MPs from GPA patients increase platelet reactivity to ADP. (A) Calcein-labeled platelets were exposed to GPA patient-derived MPs at an MP-to-platelet ratio of 10:1 and then treated with ADP (1uM) prior to assessment of activation by PAC-1 immunostaining. Mean fluorescence intensity is shown using 2 patient samples. (B) Flow cytometry scattergrams from the 2 patient sample studies showing PAC-1 fluorescence on X axis and calcein fluorescence on Y-axis. ADP, adenosine diphosphate; FL2-H, fluorescence label; GPA, granulomatosis with polyangiitis; IgM, immunoglobulin M; MP, microparticle; NT, non reated; PAC-1, platelet activation clone.