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. 2016 May 10;10:88. doi: 10.3389/fnbeh.2016.00088

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Copyright © 2016 Muralidharan, Kuo, Jacob, Lourdesamy, Carvalho, Nicholson, Corradini and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cumulative (A) mean (±SEM) PV and (B) mean (±SEM) PPT vs. time curves for Cohorts 1–3 rats administered a unilateral ip.l. injection of FCA (n = 11), relative to that of rats that received a unilateral ip.l. injection of saline (n = 8). Between days 2 and 14 post-ip.l. injection, there was significant (P ≤ 0.05) temporal development of edema and mechanical hyperalgesia in the ipsilateral hindpaws of FCA-rats c.f. the corresponding values for the ipsilateral hindpaws of sham-rats. Ipsi, Ipsilateral hindpaw; Contra, Contralateral hindpaw. ^*P ≤ 0.05 (Two-way ANOVA, post-hoc: Bonferroni) relative to saline-injected sham-rats.