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. 2016 May 10;10:88. doi: 10.3389/fnbeh.2016.00088

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Copyright © 2016 Muralidharan, Kuo, Jacob, Lourdesamy, Carvalho, Nicholson, Corradini and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cumulative mean (±SEM) PWT vs. time curves for Cohorts 1–4 CCI- (n = 21) and sham (n = 16)-control rats. For CCI-rats, there was a significant (P > 0.05) temporal reduction in the mean (±SEM) PWTs of the ipsilateral hindpaw between days 2 and 14 post-CCI surgery, relative to that of the mean (±SEM) PWT values of the ipsilateral hindpaw of sham-control rats or the contralateral hindpaw of CCI-rats. ^*P ≤ 0.05 (Two-way ANOVA, post-hoc: Bonferroni) relative to sham-group rats.