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. 2016 May 9;213(3):301–303. doi: 10.1083/jcb.201604076

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© 2016 Ioannou and McPherson

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Development of a lumenal vessel as the surrounding epithelial cells divide. PCX is indicated and the protrusions from the protein represent negatively charged sialylation. The lines indicate repulsive charge interactions that help to open and stabilize the vascular lumen. The inset shows the redistribution of PCX (blue) from the plasma membrane on single cells to recycling endosomes and finally the apical membrane as the lumen of a 3D structure (cyst, blood vessel, etc.) develops.