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. Author manuscript; available in PMC: 2016 May 10.
Published in final edited form as: Int Rev Neurobiol. 2011;99:23–50. doi: 10.1016/B978-0-12-387003-2.00002-1

Figure 6. Synaptic model of drug tolerance.

Figure 6

Shown is a schematic representation of a synapse current knowledge of putative interactions between synaptic proteins. Synaptic proteins that have been implicated in the development of tolerance to alcohol and anesthetics are displayed and labeled in black. These proteins include Synapsins (Syn), Dynamin (Dyn), Homer, Integrins, BK channels (BK), Syntaxin 1A (Syx), and the GABAB receptor (GABABR). Proteins and structures in gray are included to provide context. Thin dotted lines with arrows denote known protein-protein interactions. Figure adapted from Gorini et al. (2010).