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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2016 Apr 2;24(11):2451–2465. doi: 10.1016/j.bmc.2016.04.006

Scheme 2.

Scheme 2

Synthesis of compounds 27-73. Reagents and conditions: a) Boc2O, Montmorillonite K-10; b) NaHS·xH2O, MgCl2, 15-crown-5-, DMF, rt; c) appropriate 1-aryl-2-bromoethanone, EtOH, reflux;; d) appropriate carbonyl or sulfonyl chloride, anhydride, or isocyanate, Et3N (or DIEA), THF (or DCM). Structures 27-55 and 56–73 are defined in Tables 2 and 3, respectively.