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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Anal Chem. 2016 Apr 14;88(9):4584–4599. doi: 10.1021/acs.analchem.5b04772

Scheme 2.

Scheme 2

DNA Adduct Formation from Metabolic cyt P450 Bioactivation of (a) Styrene, (b) N-Nitrosopyrrolidine (NPYR), (c) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), (d) N-(9H-Fluoren-2-yl)acetamide (2-AAF), and (e) Benzo[a]pyrene (B[a]P)