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. Author manuscript; available in PMC: 2017 May 3.
Published in final edited form as: Anal Chem. 2016 Apr 14;88(9):4584–4599. doi: 10.1021/acs.analchem.5b04772

Figure 4.

Figure 4

Microfluidic device for cell culture, metabolite analysis and cytotoxicity assay. (a) The integrated microfluidic device. (b) Microchannels for HLM encapsulation by PEG hydrogels. (c) Design of the on-chip micro-SPE column. (d) Cell culture channel. (e) An image of the microfluidic device filled with a blue dye in the bioreactor part cell culture part. Reproduced from Mao, S.; Gao, D.; Liu, W. et al. Lab Chip, 2012, 12, 219–226 (ref 58), with permission, copyright Royal Society of Chemistry, 2012.