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. 2015 Nov 17;108(1):djv303. doi: 10.1093/jnci/djv303

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — PDL1 expression after in vivo delivery of miR-34a. Analysis of miR-34a and PDL1 expression levels in subcutaneous 344SQ tumors treated with MRX34 (n = 2) by quantitative polymerase chain reaction (A), by western blotting (C), by flow cytometry (B) (P = .04, n = 2; an unpaired t test was used to calculate the two-sided P value) (D), or by immunohistochemical staining (E) in a syngeneic mouse model. Scale bar = 200 μm. F) MRX34-induced downregulation of PDL1 in an H1299 xenograft model described elsewhere (37). Magnification ×100. Scale bar = 100 μm. *P < .05. Error bars on the bar charts represent standard deviation. ctrl = control; IHC = immunohistochemistry; MRX34 = miR-34a–loaded liposomes.