Table 2.

Result rank definitions*

Rank integer	General definition	Inhibition ranges	HFE	MMOC
0	Not efficacious (NE)	<20%	< Minimum criterion for a positive result	<60%
1	Weak positive (+)	20 – <50%	Minimum positive criterion – <50%	60 – <75%
2	Moderate positive (++)	50 – <75%	50 – <75%	75 – <90%
3	Strong positive (+++)	≥75%	≥75%	≥90%

* Results were normalized by assignment of a rank integer corresponding to the strength of positivity of the result. All animal efficacy and most morphologic assays used the general inhibition ranges shown in the third column. Human foreskin epithelial cell (HFE) and mouse mammary organ culture (MMOC) assays used slightly different scales (columns 4 and 5) based on the less quantitative nature of weak positive results (HFE) or an increased stringency for MMOC results that better correlates with animal mammary results. HFE = human foreskin epithelial cell; MMOC = mouse mammary organ culture.