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Effect of T-DM1 on survival of mice with established human epidermal growth factor receptor 2–positive breast cancer brain metastases. Kaplan-Meier survival analysis of mice bearing BT474-Gluc (A) or MDA-MB-361-Gluc tumors (B) in the brain after treatment with control IgG, trastuzumab, or T-DM1 (15mg/kg) (n = 9–11). All statistical tests were two-sided.
