Table 1.

Genes involved in sleep regulation in Drosophila.

Protein function	Gene	Reference
Neurotransmission	Dopamine transporter	Kume et al., 200553
	Dopamine 1-like receptor 1	Ueno et al., 201254
	5-hydroxytryptamine (serotonin) receptor 1A	Yuan et al., 200655
	Tyramine β hydroxylase	Crocker and Sehgal, 200856
	Tyrosine decarboxylase 2	Crocker and Sehgal, 200856
	Octopamine receptor in mushroom bodies	Crocker et al., 201057
	Resistant to dieldrin (GABAAreceptor)	Agosto et al., 2008; Chung et al., 201431,58
	Wide awake	Liu et al., 201459
	GABA transaminase	Maguire et al., 201560
	nicotinic Acetylcholine Receptor α4	Shi et al., 201429
	nicotinic Acetylcholine Receptor α2	Wu et al., 201461
	NMDA receptor 1	Tomita et al., 201562
	Pigment-dispersing factor	Parisky et al., 200830
	Ecdysone receptor	Ishimoto and Kitamoto, 201063
	Sex Peptide	Isaac et al., 200964
	Myoinhibiting peptide precursor	Oh et al., 201465
	Sex peptide receptor	Oh et al., 201465
	short neuropeptide F precursor	Shang et al., 201366
	Diuretic hormone 31	Kunst et al., 201467
	SIFamide	Park et al., 201468
	SIFamide receptor	Park et al., 201468
Ion channel signaling	Shaker	Cirelli et al., 200526
	Hyperkinetic	Bushey et al., 200769
	quiver (sleepless)	Koh et al., 200815
	Ca2+-channel protein α1 subunit T	Jeong et al., 201570
	Calcineurin B	Nakai et al., 2011; Tomita et al., 201171,72
	Calcineurin A1	Nakai et al., 2011; Tomita et al., 201171,72
	sarah	Nakai et al., 201172
	Sulfonylurea receptor (ATP-sensitive potassium channel subunit)	Allebrandt et al., 201373
	Transient receptor potential cation channel A1 ortholog	Roessingh et al., 201574
Cell cycle regulation	Cyclin A	Rogulja and Young, 201216
	Regulator of cyclin A1	Rogulja and Young, 201216
	taranis	Afonso et al., 20159
	Cyclin-dependent kinase 1	Afonso et al., 20159
Synaptic development	Fmr1	Bushey et al., 200975
	homer	Naidoo et al., 201276
	Neuroligin 4	Li et al., 201377
	Neurexin 1	Larkin et al., 201578
Cellular signaling	Rolled (ERK)	Foltenyi et al., 2007; Vanderheyden et al., 2013)79,80
	Epidermal growth factor receptor	Foltenyi et al., 200780
	spitz	Foltenyi et al., 200780
	Star	Foltenyi et al., 200780
	rhomboid	Foltenyi et al., 200780
	Gold tip	Guo et al., 201181
	Notch	Seugnet et al., 201182
	Delta	Seugnet et al., 201182
	bunched	Seugnet et al., 201182
	basket	Takahama et al., 201283
	foraging	Donlea et al., 201284
	crossveinless c	Donlea et al., 201485
Metabolism	Insulin-like receptor	Metaxakis et al., 201486
	Ribosomal protein S6 kinase	Metaxakis et al., 201486
	forkhead box, sub-group O	Metaxakis et al., 201486
	Lipid storage droplet-2	Thimgan et al., 201087
	brummer	Thimgan et al., 201087
	fatty acid binding protein	Gerstner et al., 201188
Circadian	period	Hendricks et al., 200089
	cycle	Hendricks et al., 2000; Shaw et al., 200212,90
Immune/stress response	Heat shock protein 83	Shaw et al., 200212
	Relish	Williams et al., 200791
	bipolar oocyte (bip)	Naidoo et al., 201276
	Anaplastic lymphoma kinase	Bai and Sehgal, 201592
Protein degradation	Ubiquitin protein ligase E3A	Wu et al., 200893
	insomniac	Pfeiffenberger and Allada, 2012; Stavropoulos and Young, 201114,94
Learning and memory	Cyclic-AMP response element binding protein B	Hendricks et al., 200195
	dunce	Hendricks et al., 200195
	rutabaga	Hendricks et al., 200195
	Protein kinase, cAMP-dependent, regulatory subunit type 1	Crocker and Sehgal, 200856
	amnesiac	Liu et al., 200896
Other	Catecholamines up	Harbison et al., 200997
	Tat interactive protein 60kDa	Pirooznia et al., 201298
	yellow-achaete intergenic RNA	Soshnev et al., 201199
	Activating transcription factor-2	Shimizu et al., 2008100
	Adar	Robinson et al., 2016101