Figure 4.

A) Univariate analyses for overall survival (OS) of patients with mutations of IDH1, IDH2, or TET2 individually or in combination in The Cancer Genome Atlas (TCGA) Research Network dataset. Kaplan-Meier survival curves were drawn for each gene. Note that none of them have an effect on the survival. P values are derived from the two-sided log-rank test. B) Kaplan-Meier survival curves for OS of patients based on their TET2-specific differentially methylated CpGs (tet2-DMC) and TET2/IDH mutation status. The tet2-DMC–low status (blue) shows the longest survival, followed by the tet2-DMC–high with TET2/IDH mutations (red) and the tet2-DMC–high without TET2/IDH mutations (orange). MT = mutant; WT = wild type.