FIG 3.

Amino acid sequence alignment of VCC-1 with the sequences of previously described class A carbapenemases. Signature motifs of β-lactamases are boxed. Coordinates for each protein are indicated at the end of each line. Numbering above the alignment refers to Ambler coordinates for class A β-lactamases. Starting at Ambler position 35, asterisks (*) indicate completely conserved amino acids and periods (.) indicate positions with structurally related amino acids. GenBank accession numbers are listed in the legend to Fig. 2.