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Continuous (CoI) versus intermittent (InI) vancomycin infusion impact on mortality and nephrotoxicity has been evaluated through a systematic review and meta-analysis of vancomycin for the treatment of Gram-positive infections (34). The global mortality was not different between patients on CoI versus those on InI (RR, 1.03; 95% CI, 0.7 to 1.6; P = 0.9). On the contrary, nephrotoxicity was higher in patients receiving vancomycin InI than in those with CoI (P = 0.02).
