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(Top) Mean plasma profiles of BAL4815 after single oral-dose administration of BAL8557 prodrug equivalent to active compound of 20, 40, 60, and 90 mg/kg/day. (Bottom) Mean plasma profiles of isavuconazole after oral dose administration of prodrug isavuconazonium sulfate for 6 days to the infected animals. A loading oral dose of 90 mg/kg of isavuconazole was administered, followed by once-daily maintenance doses of 20, 40, and 60 mg/kg.
