FIG 5.

(Top) Concentrations of isavuconazole (BAL4815) in the lung tissue after oral administration of BAL8557 for 12 days to the infected animals. An initial loading dose of 90 mg/kg of isavuconazole was administered orally, and thereafter the drug was administered daily at 20, 40, and 60. (Bottom) Concentrations of isavuconazole in the BAL fluid and BAL fluid supernatant after oral administration of prodrug isavuconazonium sulfate for 12 days to the infected animals. An initial loading dose of 90 mg/kg of isavuconazole was administered orally, and thereafter the drug was administered daily at 20, 40, and 60 mg/kg.