TABLE 1.

Pharmacokinetic parameters of isavuconazole (BAL4815) after oral administration of isavuconazonium (BAL8557) prodrug equivalent to active compound of 20, 40, 60, and 90 mg/kg/day

Dose (mg/kg p.o.)	AUC0–24 (ng · h/ml)		CL (ml/h/kg)
	Single dose	6 doses to infected rabbits
20	3.3 × 103 ± 0.4 × 103	59.7 × 103 ± 13.8 × 103	15.7 ± 3.1
40	5.9 × 103 ± 0.8 × 103	141 × 103 ± 32.9 × 103	17.8 ± 2.3
60	32.8 × 103 ± 6.7 × 103	197 × 103 ± 27.8 × 103	3.4 ± 0.9
90	58.2 × 103 ± 7.4 × 103	—a	2.0 ± 0.6

^a—, 90 mg/kg/day was administered only on day 1 to measure the exposure of a single loading dose.