FIG 5.

Other compounds that inhibit known cellular targets have no effect on virus replication. (A) Cells were infected with CV-B3 or mock infected and treated with the indicated concentrations of salmeterol. At 8 h p.i., virus titers were determined by endpoint titration. Cell viability was measured by using the MTS assay. (B) Cells were infected with CV-B3 and treated with the indicated concentrations of the β2-AR antagonist ICI-118,551 (ICI) in the absence (DMSO) or presence of 5 μM formoterol (form). At 8 h p.i., virus titers were determined by a limiting-dilution assay. (C) Cells were infected with CV-B3–Rluc or mock infected and treated with various concentrations of the indicated compounds. At 6 h p.i., Renilla luciferase activity was measured. Cell viability was determined by using the MTT assay.