TABLE 3.
Summary of the pharmacokinetic parameters of NP085 and NP102 following oral and i.v. administration in mice
| Parameter | Value of the parameter by administration route (mean ± SEM)a |
|||
|---|---|---|---|---|
| NP085 |
NP102 |
|||
| Oral | i.v. | Oral | i.v. | |
| Cmax (μM) | 0.16 ± 0.04 | 0.7 ± 0.3 | ||
| Tmax (h) | 0.5 ± 0 | 0.5 ± 0 | ||
| Elimination half-life (h) | 5.9 ± 3.7 | 6.1 ± 0.4 | 4.6 ± 0.9 | 6.1 ± 0.1 |
| CL (ml/min/kg) | 105.7 ± 17.4 | 60.1 ± 8.5 | ||
| V (liters/kg) | 56.7 ± 13.5 | 32.4 ± 7.6 | ||
| AUC0-∞ (min · μmol/liter) | 36 ± 9 | 145 ± 21 | 147 ± 40 | 226 ± 29 |
| Bioavailability (%) | 8 ± 2 | 22 ± 6 | ||
a
The doses were 15 mg/kg and 5 mg/kg for oral and i.v. administration, respectively.