TABLE 1.
Replicon profiles of grazoprevir and elbasvir in HCV genotypes 1 to 6
| Sequence identificationa | Grazoprevir |
Elbasvir |
||
|---|---|---|---|---|
| EC50 (nM)b | EC90 (nM) | EC50 (nM) | EC90 (nM) | |
| GT1a (NC004102, H77) | 0.4 ± 0.2 | 0.9 ± 0.5 | 0.004 ± 0.002 | 0.006 ± 0.002 |
| GT1b (AJ238799, Con1) | 0.5 ± 0.3 | 1.1 ± 0.6 | 0.003 ± 0.001 | 0.006 ± 0.004 |
| GT2a (AB047639, JFH1) | 2.3 ± 1.2 | 7.1 ± 3.1 | 0.003 ± 0.001 | 0.019 ± 0.01 |
| GT2b (AY232740) | 3.7 ± 1.1 | 7.8 ± 2.1 | NA | NA |
| GT2b (AB030907) | NA | NA | 3.4 ± 2.6 | 11 ± 4.8 |
| GT2b (AB030907) M31L | NA | NA | 0.32 ± 0.38 | 1.0 ± 1.2 |
| GT3a (GU945445, GU945457.1) | 7.6 ± 3.2 | 20.5 ± 9.0 | NA | NA |
| GT3a (GU814263, S52), catalytic | 2.1 ± 1 | 10.2 ± 1.0 | NA | NA |
| GT3a (S52), full-length | 35 ± 15 | 153 ± 35 | 0.14 ± 0.09 | 0.49 ± 0.19 |
| GT3a (NC009824) | NA | NA | 0.03 ± 0.01 | 0.12 ± 0.06 |
| GT4a (GU814265, ED43) | 0.3 ± 0.2 | 0.8 ± 0.4 | 0.0003 ± 0.0001 | 0.0005 ± 0.0001 |
| GT5a (AF064490, SA13) | 6.6 ± 0.6 | 12.8 ± 2.2 | 0.001 ± 0.001 | 0.002 ± 0.002 |
| GT6a_(JN180455.1) | 0.9 ± 0.1 | 2.3 ± 0.4 | NA | NA |
| GT6 (DQ278892) | 0.2 ± 0.04 | 0.3 ± 0.1 | 0.009 ± 0.006 | 0.017 ± 0.009 |
a
Numbers in parentheses are GenBank accession numbers and/or strain designations. Additional details about the replicons are in Table S1 in the supplemental material. Parental replicons of Con1 (GT1b) and JFH1 (GT2a) were used as controls.
b
Values are means ± standard deviations (n ≥ 3). NA, not available.