TABLE 2.

Patient characteristics by CART-derived AUC₂₄/MBC breakpoint for VAN in MRSA-B

Characteristica	Value by AUC24/MBC category		P value
	<176 (n = 21)	≥176 (n = 32)
Age (years), means ± SD	67.6 ± 15.5	55.2 ± 15.9	0.007
≥65 yr, n (%)	13 (61.9)	11 (34.4)	0.049
≥85 yr, n (%)	4 (19.0)	0 (0.0)	0.020
Female gender, n (%)	6 (28.6)	12 (37.5)	0.502
Previous VAN exposure within 30 days, n (%)	7 (33.3)	2 (6.2)	0.021
Hospital-acquired MRSA-B, n (%)	11 (52.4)	7 (21.9)	0.022
ICU, n (%)	8 (38.1)	8 (25.0)	0.310
Sepsis, n (%)	16 (76.2)	20 (62.5)	0.296
Septic shock, n (%)	6 (28.6)	2 (6.2)	0.047
Immunosuppression, n (%)	4 (19.0)	10 (31.2)	0.324
MRSA-B focus, n (%)
High risk	10 (47.6)	8 (25.0)	0.089
Medium risk	7 (33.3)	21 (65.6)	0.021
Low risk	4 (19.0)	3 (9.4)	0.415
MRSA bacteriuria, n (%)	2 (9.5)	2 (9.4)	1.000
Diabetes mellitus, n (%)	7 (33.3)	12 (37.5)	0.757
Alcoholism, n (%)	1 (4.8)	4 (12.5)	0.637
Cirrhosis, n (%)	0 (0.0)	4 (12.5)	0.143
Congestive heart failure, n (%)	5 (23.8)	0 (0.0)	0.007
Malignancy, n (%)	7 (33.3)	8 (25.0)	0.546
HIV positive, n (%)	0 (0.0)	1 (3.1)	1.000
Chronic obstructive pulmonary disease, n (%)	4 (19.0)	3 (9.4)	0.415
Charlson comorbidity index, median (IQR)	7 (5–9)	6 (3–7)	0.058
PBS, median (IQR)	2 (1–4)	2 (0–4)	0.528
PBS ≥ 4, n (%)	5 (23.8)	8 (25.0)	0.922
APACHE II, median (IQR)	13 (9–18)	10 (7–15)	0.084

^aIQR, interquartile range.