TABLE 4.
Correlations between the fecal acetic acid levels and tight-junction-related gene expression in the intestinal epithelium on day 14 after MDRAb infection
| Site and gene producta | Correlation between fecal acetic acid levels and tight-junction-related gene expression (n = 24) |
|
|---|---|---|
| Pearson correlation coefficient | P | |
| Ileum | ||
| Claudin-1 | 0.470 | <0.05 |
| Occludin | 0.695 | <0.001 |
| ZO-1 | 0.559 | <0.01 |
| Cecum | ||
| Claudin-1 | 0.503 | <0.05 |
| Occludin | 0.597 | <0.01 |
| ZO-1 | 0.730 | <0.001 |
| Colorectum | ||
| Claudin-1 | 0.659 | <0.001 |
| Occludin | 0.761 | <0.001 |
| ZO-1 | 0.856 | <0.001 |
a
Mice were infected with MDRAb, treated with BbY plus GOS, and treated with 5-FU, as described in the legend to Fig. 4. Feces were collected immediately before dissection of the mice (6 mice/group) on day 14 after infection with MDRAb, and the organic acid concentration was measured.