TABLE 1.
Total clofazimine concentrations during and after treatment in sera of mice that were administered clofazimine (alone or in combination)a
| Regimen | Mean (SD) serum clofazimine concn (μg/ml) at time point(s) (wk treatment + wk posttreatment) of: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 4 + 2 | 4 + 4 | 4 + 6 | 4 + 8 | 8 | 8 + 2 | 8 + 4 | 8 + 6 | 8 + 8 | |
| C alone | 1.19 (0.48) | 0.21 (0.28) | 0.16 (0.08) | 0.07 (0.04) | 0.09 (0.12) | 1.55 (0.85) | 0.38 (0.08) | 0.40 (0.24) | 0.13 (0.07) | 0.06 (0.03) |
| RHZC | 1.01 (0.33) | 0.48 (0.55) | 0.20 (0.09) | 0.18 (0.21) | 0.10 (0.04) | 1.73 (0.52) | 0.65 (0.30) | 0.28 (0.10) | 0.13 (0.07) | 0.10 (0.08) |
a
H, isoniazid at 10 mg/kg; R, rifampin at 10 mg/kg; Z, pyrazinamide at 150 mg/kg; E, ethambutol at 100 mg/kg; C, clofazimine at 25 mg/kg.