FIG 4.

Inhibitory effects of anti-TB drugs on 1 μM rosuvastatin uptake in stably transfected HEK-OATP1B1 cells. OATP1B1-mediated (in the absence of any uptake inhibitor) uptake, as a control, was compared with uptake inhibition by the TB drugs. Rifampin (RIF) was used as a positive control for OATP1B3-mediated uptake inhibition. Data represent the means ± standard errors (SE) from triplicate experiments (n = 3). *, P < 0.05, **, P < 0.01, and ***, P < 0.001, significantly different compared with percentage of uptake in controls (no inhibitor).