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Replication of unmodified replicons and mutants with low-CpG/UpA luciferase. Shown are data for the replication of genotype 2a (A), 1b (B), 3a (C), and 4a (D) replicons after electroporation into Huh7.5 cells. Luciferase activity was measured at four time points (x axis) and plotted as absolute values (y axis). Error bars represent standard deviations. RLU, relative light units.
