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Testing of susceptibility of original and modified replicons to sofosbuvir (Sofos.). Shown are data for the inhibition of replication of CpG-low and WT luciferase replicons 1b/l-GDD and 1b/L-GDD (A), 3a/LN-GDD and 3a/L-GDD (B), and 4a/LN-GDD and 4a/l-GDD (C) with differing concentrations of sofosbuvir. The experiment was performed with the Huh7.5 and 23 cell lines. Error bars depict standard deviations.
