TABLE 2.
IC50s for sofosbuvir in genotypes 1b (Con1), 3a (S52), and 4a (ED43)
| Cell line | Replicon | Mean IC50 ± SDa |
||
|---|---|---|---|---|
| 48 h p.e. | 72 h p.e. | 96 h p.e. | ||
| Huh7.5 | 1b/L-GDD | — | — | — |
| 1b/l-GDD | — | — | — | |
| 3a/LN-GDD | 48 ± 4 | 42 ± 1 | 57 ± 2 | |
| 3a/L-GDD | 53 ± 8 | 47 ± 9 | 40 ± 2 | |
| 4a/LN-GDD | — | — | — | |
| 4a/l-GDD | — | — | 49 ± 27 | |
| 23 | 1b/L-GDD | — | — | — |
| 1b/l-GDD | 95 ± 8 | 42 ± 4 | 55 ± 6 | |
| 3a/LN-GDD | 35 ± 3 | 38 ± 6 | 29 ± 1 | |
| 3a/L-GDD | 42 ± 3 | 41 ± 2 | 29 ± 1 | |
| 4a/LN-GDD | — | — | 28 ± 10 | |
| 4a/l-GDD | — | 45 ± 15 | 39 ± 1 | |
a
IC50s are the concentrations of sofosbuvir that inhibit the HCV replicon by 50%. —, not determined (insufficient replication).