Recalculated networks after the subsequent removal of variants with the highest betweenness. Variants are colored according to their phenotype (2b, green; 2be, blue; 2br, red; 2ber, pink; unknown, gray). Variants with the highest betweenness are colored yellow. (A) Cluster 1 remaining after the removal of TEM-1. Cluster 2 with TEM-116 as the central variant is not shown. Variants marked with the highest betweenness are TEM-12, TEM-2, TEM-33, TEM-135, and TEM-63. (B) Cluster 1 split after the removal of variants into clusters A and B. The variant marked with the highest betweenness is TEM-110. (C) Cluster B split after the removal of variants into clusters B.1 and B.2.